Alginate Hydroxyapatite Films with Potential Use in Bone Disease

LUCIANO BENEDINI; DAMIAN PLACENTE; OLGA PIERONI; PAULA V. MESSINA

Buenos Aires

Workshop; II Workshop on Bio-degradable Polymers and Biocomposites, III Workshop BIOPURFIL, Bio-based Polyurethane Composites with Natural Fillers; 2015

Bone filling materials made from hydroxyapatite (Ca10(PO4)6(OH)2), (HA) are used for treating bone deficiencies caused by disease or injury. This material promotes the reproduction of new bone by injection into bone defects. Even though HA has been utilized as a bone-filling material, it requires a long time to be replaced with host bone after implantation. Composite materials based on HA and hydro-gels would be suitable to fill large bone defects and would be easily absorbed by the patient´s body. Furthermore these materials could be used for drug carrier. The aim of this work is to compare the effect of Ca2+ concentration in HA suspensions and CaCl2 solutions in the gelation and bioactivity of alginate films; towards its future application in biodegradable and bioadhesive wound dressing applied to bone injury or defects.