Interaction of magnetic nanoparticles with phospholipids in Langmuir monolayers

ALEJANDRO MENZAQUE; ANABEL LANTERNA; BRUNO MAGGIO; ALEJANDRO GRANADOS; KRAUSE R.; RAQUEL VICO

Villa Carlos Paz

Congreso; XLII Reunión Anual de la Sociedad Argentina de Biofísica; 2013

Sociedad Argentina de Biofísica

A growing number of innovations have emerged in the fields of nanobiotechnology/nanomedicine and new engineered nanomaterials are posing new challenges to understand the full spectrum of interactions at the nano-bio interface. Among them, magnetic nanoparticles (MNP) are greatly promising because of their potential application in fields such us drug delivery, magnetic resonance imaging (MRI), heat source in magnetic fluid hyperthermia.1We are studying the interaction of MNPs with phospholipids in Langmuir monolayers with the aim of identify the influence of nanoparticle surface functionalization in their biomolecular properties. Here we present the results of the interaction of MNPs covered with Oleic Acid (MNP@OA) and Stearic Acid (MNP@SA) with dipalmitoylphosphatidylcholine (DPPC). The presence of either MNP cause phase condensation of DPPC with respect to the pure phospholipid and significantly modify the surface topography of DPPC (observed by BAM) along the whole isotherm, even if the MNP constitute only a small mole fraction of the mixture.1Mout, R., Moyano, D., Rana, S., Rotello, V. Chem. Soc. Rev. 2012, 2539.