CHAGAS DISEASE VACCINE BASED ON ANTIGEN ENGINEERING & STING AGONIST

ANDRES SANCHEZ ALVERTI; AUGUSTO E BIVONA; NATACHA CERNY; SILVIA INES CAZORLA; CARDOZO LANDABURU A; SHULZE K; WEISSMAN S; EBENSEN, T; PADILLA A; TARLETON RL; GUZMAN C; EMILIO MALCHIODI

Capital Federal

Congreso; IV LASID Meeting; 2015

SAI

T. cruzi is an obligatory intracellular parasite recognized by WHO as a neglected tropical disease, which affects 12 million people in Latin America. After 100 years of its discovery, there are still no effective vaccines to prevent or treat the infection.CHAGAS DISEASE VACCINE BASED ON ANTIGEN ENGINEERING & STING AGONIST In this work we employed rational design of the immunogen based in the three dimensional structure, in order to present a multivalent display of key parasitic cytotoxic T lymphocyte (CTL) and antibody targets as well as to omit known immune evasion associated sequences. In search for novel components to increase the levels of CTL response, we have employed cyclic di nucleotides (CDNs) ? 3?5?-c-di-AMP (a STING agonist) with recombinant (r) Protein or DNA-prime + rProtein-boost ? in vaccination protocols by the intranasal route.