Neurofilament phosphoform and cytokines levels in 5 years evolution patients with RRMS as surrogate blood-markers for axonal injury and inflammation

CAPANI F(1), FILIPPO M, TAU J,, GOLINELLI B , KÖLLIKER FRERS R. A. VILLA A

Rio de Janeiro

Congreso; International Brain Research Congress; 2015

Multiple sclerosis (MS) is an immune mediated disease that damages the central nervous system. Although several clinical forms exist, relapsing-remitting multiple sclerosis (RRMS) is the most common disease course at the time of diagnosis. It is characterized by clearly defined attacks of worsening neurologic function, often called relapses, or exacerbations ? which are followed by partially or completely recovery periods (remissions), but underlying progression of the disease persist. Early diagnostic is critical to prevent the long-term disability. Therefore, the main aim of this study was to perform a transversal study for comparing the blood levels of the phosphorylated neurofilament. (pNF-H), inflammatory (TNF, IL1β, 6, 8 y 17, MCP1 e ICAMs) and anti-inflammatory markers TGFβ e IL10) using ELISA. To establish the real clinic relevance selected markers were compared separately or associated with their clinical score (CS). RRMS patients were chosen according with McDonald criteria, clinical score values (below 6.0) and 5 year of evolution. We observed a significant increment for pNF-H (p