Ketorolac Tromethamine release contained in SBA-15 and CMK-3 mesoporous materials

JULIANA M. JUÁREZ; JORGELINA CUSSA; MARCOS B. GÓMEZ COSTA; OSCAR A. ANUNZIATA

Perugia

Congreso; 11th International Conference "Medical Applications of Novel Biomaterials and Nanotechnology" CIMTEC 2016; 2016

CIMTEC

Nanostructure silicate SBA-15 and it´s replica CMK-3 were synthesized with potential applications as a drug delivery agent. The Silica mesoporous material was prepared by sol?gel method and the ordered nanoporous carbon CMK-3 was synthesized via a two-step impregnation of the SBA-15 mesopores with a solution of sucrose using an incipient wetness method. The resultant samples were haracterized with XRD, FTIR, XPS, BET, TEM and SEM. The drug, ketorolac tromethamine, KETO (non-steroidal anti-inflamatory drug) was dissolved in ethanol with vigorous stirring, and then the mesopourous materials were added. In this way, the drug was introduced into the pore channels and its delivery to the media has been measured and compared. The drug release was evaluated by soaking 30 mg of Host/KETO in 15 ml of stirred SBF (Simulating Body Fluid) at 310K. The analysis was made through UV?vis spectrophotometry to assess the amount of KETO released. In both samples there is an initial burst release, probably due to the excessive ketorolac tromethamine located on the external surface of the silica or weakly entrapped inside the mesopores. However, after the initial fast delivery, there is a slower release of the residualbulkier drug. The drug release in the case of the siliceous SBA-15 host is faster than the CMK-3´s. This behavior is opportune for drug delivery systems that should release drugs gradually at a constant rate, thereby maintaining drug concentration (in vivo) within the range of the therapeutic efficacy.