CIVETAN   23983
CENTRO DE INVESTIGACION VETERINARIA DE TANDIL
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
The T687G SNP in a P- glycoprotein gene of F. hepatica is not detected in different strains susceptible and resistant to triclabendazole
Autor/es:
SOLANA M.V.; SOLANA H.; ORTIZ OBLITAS P.; MIRANDA-MIRANDA E.; TORT J.
Lugar:
Philadelphia
Reunión:
Conferencia; International Conference on Parasitology; 2015
Institución organizadora:
OMICS International & Journal of Bacteriology & Parasitology
Resumen:
Fasciolosis
is a parasitic disease caused by the trematode Fasciola hepatica. Its
control is mainly based on the use of triclabendazole (TCBZ), a halogenated
benzimidazole with excellent efficacy against juvenile and adult stages.
Resistance to TCBZ in F. hepatica has been reported in many parts of the
world. Benzimidazole resistance in nematodes is mainly caused by specific amino
acid substitutions in β-tubulin resulting from a nucleotide substitution in the
gene. However, the resistance to TCBZ in F. hepatica is not associated
with changes in this molecule. The increased cellular efflux of TCBZ in F.
hepatica is related to ABC transporters as the P-glycoproteins (PGP). In
this protein single nucleotides polymorphisms (SNPs) were identified, such as
T687G which was associated with the phenomenon of resistance (Wilkinson et
al, 2012). Other SNPs not yet associated with resistance were also
identified (A617T and T267G).