INVESTIGADORES
REPETTO Marisa Gabriela
congresos y reuniones científicas
Título:
The effect of the transition metal ions (nickel, cobalt, and copper) on lipid peroxidation and oxidative damage
Autor/es:
DALGHI, MARIANELA; REPETTO, MARISA
Lugar:
Montevideo
Reunión:
Congreso; V Meeting of SFRBM-South American Group. V International Conference on Peroxynitrite and Reactive Nitrogen Species.; 2007
Institución organizadora:
SFRBM-South American Group
Resumen:
The transition metals ions nickel, cobalt >and copper Ni 2+ ions do not induce either lipid peroxidation by themselves, or H2O2decomposition. Nevertheless, Ni2+ and Cu2+ mixed with Fe2+, stimulate the Fe2+ initiated lipid peroxidation by a positive competitive mechanism (t1/2: 45 and 40 min respectively) and Co2+ inhibits Fe2+ initiated lipid peroxidation (t1/2: 16 min). The presence of Cu2+ and Ni2+ stimulate the initial phase of lipid peroxidation catalyzed by Fe.
