INVESTIGADORES
REPETTO Marisa Gabriela
congresos y reuniones científicas
Título:
Oxidative processes of brain damage induced by copper and iron.
Autor/es:
MUSACCO SEBIO, ROSARIO; SAPORITO MAGRIÑÁ, CHRISTIAN; FERRAROTTI, NIDIA; REPETTO, MARISA
Lugar:
San Pablo
Reunión:
Congreso; I Sao Paulo Advanced School on Redox Processes in Biomedicine y VII Meeting of South American Group of the Society of Free Radical Biology and Medicine.; 2011
Institución organizadora:
South American Group of the Society of Free Radical Biology and Medicine.
Resumen:
Copper (Cu) and iron (Fe) toxicities are associated to the etiology of neurodegenerative diseases. The mechanisms currently considered are a Haber-Weiss reaction and a depletion of reduced glutathione (GSH) and protein SH groups. Objective: to compare oxidative damage (OD) and time course of OD induced by Cu and Fe in rat brain; to correlate OD with redox status (Pearson´s factor, r, p:8mg/kg); decreased 62% CO (D50%:5mg/kg,ti=tm 16h),
