POSSIBLE ROLE OF PLACENTAL AQUAPORINS IN APOPTOTIC PROCESSES DURING PREECLAMPSIA.

SZPILBARG, NATALIA; RECA, A; DIETRICH, VALERIA; REPETTO, MARISA; MASKIN, B; JAIME, M; CASTRO PARODI, MAURICIO; DAMIANO, ALICIA

Foz de Iguazu

Congreso; V LatinAmerican Symposium on Maternal-Fetal Interaction & Placenta-; 2013

Sociedad Latinoamericana de Fisiología

Preeclampsia is a unique human pregnancy disorder of unknown etiology that affects between 5 and 8% of pregnancies worldwide. It is characterized by a systemic inflammatory response associated with endothelial dysfunction, proteinuria , and hypertension . The current hypothesis is that occurs in two stages. In the first insufficient trophoblast invasion and differentiation , resulting in inadequate placental perfusion increase oxidative stress in the placenta is observed. In the second stage , the maternal syndrome develops characteristic symptoms. It has been proposed that oxidative stress is the link between the two stages as it contributes to an increase in apoptotic rate of syncytiotrophoblast , releasing , therefore, substances into the maternal circulation , which may induce systemic effects observed in preeclampsia .