Efeito do metilmercaptoimidazol e I131 nos marcadores de stresse oxidativo em doenca de Graves.

REPETTO, MARISA; ABALOVICH, MARCOS; LLESUY, SUSANA

Congreso; XXVIII Encontro anual da Sociedade de Fisiología de Rio Grande do Sul.; 1999

The aim of this study was to evaluate the involvement of free radicals in the active Graves´ disease through the study of the balance between antioxidants and pro-oxidants. Methods: 12 hyperthyroid patients (9 women and 3 men) of mean age 34 years with> 9 months of disease progression were studied. Parameters evaluated were: 1) chemiluminescence initiated by tert-butyl hydroperoxide (QL), 2) superoxide dismutase (500), 3) catalase (CAT), 4) glutathione plasma antioxidant capacity (TRAP). As controls 10 normal adults were used. Results: QL levels were higher in Graves´ disease (11236