Poly(3-hydroxybutyrate) membranes for enrofloxacin controlled release

MARÍA F. DIB ASHUR ; ANALIA I. ROMERO; MERCEDES VILLEGAS; JOSÉ M. BERMÚDEZ; MÓNICA L. PARENTIS

Buenos Aires

Conferencia; 6th International Conference on Science and Technology of Composite Materials (COMAT 2015; 2015

This study evaluated the enrofloxacin release from membranes constituted by PHB. Enrofloxacin is a fluoroquinolone derivative used for treating urinary tract, respiratory and skin infections in animals. Membranes with different concentration of enrofloxacin were synthesized and characterized using Differential Scanning Calorimetry (DSC), Electron Scanning Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR). SEM analysis showed the distribution of drug in polymer matrix. DSC and FTIR results indicated physical interaction between drug and polymer. In vitro drug release studies were performed using a pH 5,3 buffer acetate solution.