HISTOLOGICAL STUDY OF TISULAR LESIONS IN PREGNANT RATS INTOXICATED WITH CADMIUM

DÍAZ MC, GÓMEZ S, QUIROGA M, LANDA R, NAJLE R, BARBEITO CG

Huerta Grande Córdoba

Congreso; I Reunión Conjunta de Sociedades de Biología de la República Argentina. Huerta Grande. Córdoba. Agosto 2007; 2007

Sociedad Argentina de Biología

Cadmium (Cd) is a heavy metal of great environmental toxicological relevance. Several works were performed on the effects of low and repeated doses intoxication. However, few works deal with effects of Cd high doses. In our lab, we are studying alterations determined by single subcutaneous doses of Cd (10 mg/kg, as CdCl2) in pregnant rats. We report lesions observed in liver, kidney, spleen and lung and the relationship with their Cd tisular concentrations in each organ. Groups of 6 rats intoxicated on days 4, 7, 10 and 15 of pregnancy were used. All were sacrificed on day 20 of gestation. The above mentioned organs were collected and stained with H/E. Cd concentration was determined by atomic absorption spectrophotometry. Most common lesions were: Liver: congestion and hydric complications. Lungs: emphysema or atelectasis, necrosis and cellular infiltration. Spleen: haemorrhages and white tissue loss. Kidneys: hydric complications and tubular and corpuscular necroses. Lesions were similar for all adminstration days. These results are in correlation with Cd tisular concentrations, which were similar in the experimental groups. spleen and lung and the relationship with their Cd tisular concentrations in each organ. Groups of 6 rats intoxicated on days 4, 7, 10 and 15 of pregnancy were used. All were sacrificed on day 20 of gestation. The above mentioned organs were collected and stained with H/E. Cd concentration was determined by atomic absorption spectrophotometry. Most common lesions were: Liver: congestion and hydric complications. Lungs: emphysema or atelectasis, necrosis and cellular infiltration. Spleen: haemorrhages and white tissue loss. Kidneys: hydric complications and tubular and corpuscular necroses. Lesions were similar for all adminstration days. These results are in correlation with Cd tisular concentrations, which were similar in the experimental groups. spleen and lung and the relationship with their Cd tisular concentrations in each organ. Groups of 6 rats intoxicated on days 4, 7, 10 and 15 of pregnancy were used. All were sacrificed on day 20 of gestation. The above mentioned organs were collected and stained with H/E. Cd concentration was determined by atomic absorption spectrophotometry. Most common lesions were: Liver: congestion and hydric complications. Lungs: emphysema or atelectasis, necrosis and cellular infiltration. Spleen: haemorrhages and white tissue loss. Kidneys: hydric complications and tubular and corpuscular necroses. Lesions were similar for all adminstration days. These results are in correlation with Cd tisular concentrations, which were similar in the experimental groups. 2) in pregnant rats. We report lesions observed in liver, kidney, spleen and lung and the relationship with their Cd tisular concentrations in each organ. Groups of 6 rats intoxicated on days 4, 7, 10 and 15 of pregnancy were used. All were sacrificed on day 20 of gestation. The above mentioned organs were collected and stained with H/E. Cd concentration was determined by atomic absorption spectrophotometry. Most common lesions were: Liver: congestion and hydric complications. Lungs: emphysema or atelectasis, necrosis and cellular infiltration. Spleen: haemorrhages and white tissue loss. Kidneys: hydric complications and tubular and corpuscular necroses. Lesions were similar for all adminstration days. These results are in correlation with Cd tisular concentrations, which were similar in the experimental groups.