INVESTIGADORES
TOUZ Maria Carolina
congresos y reuniones científicas
Título:
THE MODULAR ORGANIZATION OF PROTEINPROTEIN
Autor/es:
ZAMPONI N; PEROTTI J; MIRAS S; FELIZIANI C; TAMARIT F; TOUZ MC
Reunión:
Congreso; SAIB; 2011
Resumen:
Network theory provides a framework to analyze, from a
topological point of view, large amounts of data regarding molecular
interactions and provide an integrated view of cellular function and
evolution. In the past decades, complex network approaches to cell
and molecular biology have been crucial to reveal the underlying
architecture of organismal complexity. Among all of the topological
properties that can be extracted, modularity (the tendency of
elements or links to form more connected subsets) is considered to
be one of the main organizing principles in biological networks. It
has been suggested, for example, that the modularity of bacterial
metabolic networks had experimented a reduction during evolution.
It has been also pointed out that modularity is reduced in simbiont
bacteria, but the opposite is true for obligate mammalian pathogens.
In addition, the diameter of metabolic networks of parasitic
eukaryotes tends to be similar to those of free-living eukaryotes,
suggesting that network integrity had been a structural constraint
during evolution. In this work we compare protein-protein
interaction networks of unicellular eukaryotes extracted from
STRING database, by calculating two different modularities. At first
glance, parasitic/early divergent unicellular organisms tend to have
high modularity values than non-parasitic/more derived ones.