Surface bifunctionalization of amorphous coordination polymer nanoparticles for application in nanomedicine

K. WNUK; F. NADOR; F. NOVIO; D. RUIZ-MOLINA

Congreso; 11 th International Conference on Nanosciences & Nanotechnologies ? NN14; 2014

Nanoparticles are versatile scaffolds fornumerous biomedical applications including drug delivery and bioimaging. Thesurface functionality of NPs essentially dictates their intracellular uptakeand controls their therapeutic action.  Coordinationpolymer particles (CPPs) have recently emerged as a new family ofmultifunctional nanoparticles whose chemical flexibility opens new perspectivesin biomedicine (smart drug delivery systems, bioimaging probes). These nanoobjects are able toencapsulate a wide variety of substances (drugs, metal nanoparticles, quantumdots, etc?)[1], and act as smart responsive materials. The possibility of functionalizationof the nanoparticles surface allowed building new elegant biocompatible multifunctionalplatforms with interesting applications in drug delivery, bioimaging andtargeting directionality for specific recognition [2].    As a proof-of-concept for this approach wereported the fabrication of amorphous CPPs incorporating biocompatible metalsand ligands bearing two different free functional groups placed on thenanoparticles surface. These CPPs proved to be a highly robust platform thatcan be transformed into myriad functionalities through well-known condensationreactions to attach different molecules and biomolecules. The set ofchemistries that we employed enabled a plethora of new functional improvementsfor CPPs to incorporate additional functional molecules (fluorescent dyes,biomolecules, antibodies, etc.).