Providing bi-functionality on the surface of amorphous coordination polymer nanoparticles for application in nanomedicine

K. WNUK; F, NADOR; F. NOVIO; D. RUIZ-MOLINA

Madrid

Congreso; 4th International Colloid Conference; 2014

Nanoparticlesare versatile scaffolds for numerous biomedical applications including drugdelivery and bioimaging. The surface functionality of NPs essentially dictatestheir intracellular uptake and controls their therapeutic action. Theattachment of different molecules and biomolecules on the surface can provideimproved selectivity for drug delivery applications and increase theirbiocompatibility and functionality [1]. Coordinationpolymer particles (CPPs) have recently emerged as a new family ofmultifunctional nanoparticles whose chemical flexibility opens new perspectivesin biomedicine, among them their use for smart drug delivery systems,bioimaging probes and overall in therapy and diagnosis [2]. These nanoobjects are able toencapsulate a wide variety of substances (drugs, metal nanoparticles, quantumdots, etc?), and act as smart responsive materials [3]. The possibility offunctionalization of the nanoparticles surface allowed building new elegantbiocompatible multifunctional platforms with interesting applications in drugdelivery, bioimaging and targeting directionality for specific recognition. As a proof-of-concept for thisapproach we reported the fabrication of amorphous CPPs incorporatingbiocompatible metals and ligands bearing two different free functional groups.These CPPs proved to be a highly robust platform that can be transformed intomyriad functionalities through well-known condensation reactions (Figure 1) toattach different molecules and biomolecules on the surface. The set ofchemistries that we employed enabled a plethora of new functional improvementsfor CPPs to incorporate additional functional molecules (fluorescent dyes,biomolecules, antibodies, etc.).