Mechanisms of induction and regulation of the gut mucosal immune stimulation by non pathogenic bacteria

MALDONADO GALDEANO C; DOGI C.A; BIBAS BONET, ME; CHAVES, S; PERDIGÓN, G

Conferencia; World Conference on Magic Bullets Celebrating Paul Earlich?s 150th birthday; 2004

Fermented food play an important role on the immune system stimulation. They are named probiotic bacteria and they include many acid bacteria (LAB), bifidobacteria and others. Many researches were done to demonstrate the beneficial effect on human health induced by the probiotic bacteria. Scientifical evidence showed that mucosal immune stimulation, as one of the most important property of these microorganisms considering that the oral tolerance is the main mechanisms developed by the immune cells associated to the gut (GALT), many questions must be answered to understand the mechanisms of the interaction with epithelial and immune cells by which these non-pathogenic bacteria can induce up and down regulation. Especially considering the complex network of signals in the intestinal microenvironment, between procariotic and eucariotic cells, that constitutes an effective barrier against foreign antigens. Thus the main question is addressed to answer if the behaviour of the hexogenous non-pathogenic bacteria on the GALT is different of the commensal bacteria. We demonstrated that some probiotic bacteria of the genous Lactobacillus, such as L. casei, L.