Interaction of cationic phthalocyanines with DNA. Importance of the structure of the substituents.

NOELIA LOPEZ CEBALLOS; GABRIELA A. GAUNA; MARIA C. GARCIA VIOR; JOSEFINA AWRUCH LELIA DICELIO

Congreso; 16 th International Congress on Photobiology; 2014

The interaction of novel zinc (II) cationic phthalocyanines with calf thymus (CT)-DNA was studied using absorption and fluorescence spectroscopy, as well as thermal denaturation profiles. The properties of these phthalocyanines were compared taking the structure of the macrocycle peripheral substituents into account. 2,9(10),16(17),23(24)-tetrakis[(N-butyl-N-methylammonium)ethylsulfanyl]phthalocyaninatozinc(II) tetraiodide (Pc6) [2] had a greater affinity for the CT-DNA helix than its bioisoster 2,9(10),16(17),23(24)-tetrakis[(N-dibutyl-N-methylam-monium)ethoxy]phthalocyaninatozinc(II) tetraiodide (Pc7) [2].  A sulfur bulky substituted cationic phthalocynine 2,9(10),16(17),23(24)-tetrakis[(2-trimethylammonium)ethylsulfanyl]phthalocyaninato-zinc(II) tetraiodide (Pc13) [1] was also studied in order to evaluate the influence of the substituents on intercalation.