Regulated expression of galectin-1 in normal and pathological placenta: a potential mechanism of immune privilege

RAMHORST R.; DURAND S.; RUBINSTEIN N.; TOSCANO M.; CORIGLIANO A.; GENTI S.; RABINOVICH G.

Córdoba

Congreso; VII Congreso Latinoamericano de Inmunología; 2005

Asociación Latinoamericana de Inmunología (ALAI)

Several apoptotic mechanisms contribute to the maintenance of feto-maternal tolerance, including TRAIL and Fas-FasL. To evaluate whether Gal-1 may play a role in the establishing feto-placental tolerance, we investigated Gal-1 expression in normal and pathological trophoblastic tissues. Western blot analysis and immunohistochemistry of placental tissue reveled high expression of Gal-1 in the first trimestre, which was modulated throughout gestation. Moreover, moles expressed Gal-1 at different levels and particularly JEG3 (a human choriocarcinoma cell line), expressed significantly higher levels of this protein. Functional studies revealed that condition media (CM) obtained from JEG-3 cells were able to significantly suppress proliferation of polyclonally-activated PBMC (p