Synthesis of chiral precursors to cyclobutane carbocyclic nucleosides 1,3- cis-disubstituted

ALBERTINA G. MOGLIONI, GABRIELA P. SARMIENTO, LUCAS FABIÁN, GRACIELA Y. MOLTRASIO, ROSA M. ORTUÑO.

Canela, Brasil

Congreso; 11th Brazilian Meeting on Organic Chemistry; 2005

Universidad de Santa María BRASIL

INTRODUCTIONNucleoside analogs form a major part of the antiviral agents developed for treatment of AIDS. Typical examples are the carbocyclic compounds cyclobut-A and cyclobut G, which are not only active against HIV but also against herpes simplex virus and cytomegalovirus. Now we present the synthesis of some cyclobutyl amino alcohols that will be used in the preparation of novel carbocyclic nucleosides. RESULTS AND DISCUSSION Pursuing our ongoing research on the stereoselective synthesis of cyclobutane-containing molecules from terpenes we describe herein synthetic routes to amino alcohols as precursors of cyclobutane carbocyclic nucleosides 1,3-disubstituted. In this work we describe some amino alcohols as relevant precursors of cyclobutane carbocyclic nucleosides 1,3-disubstituted. An active investigation oriented to the synthesis of such products is being carried out in our laboratories.