INICSA   23916
INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Induction of TH2-mediated allergic asthma in a mouse strain highly susceptible to develop TH1 responses
Autor/es:
GODOY, GJ; SÁNCHEZ, LR; GARCÍA, L, MALDONADO, C; MOTRICH, RD, VE RIVERO
Lugar:
Mar del Plata
Reunión:
Congreso; LIX Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica (SAIC) y LXII Reunión Anual de la Sociedad Argentina de Inmunología (SAI); 2014
Institución organizadora:
Sociedad Argentina de Investigación Clínica (SAIC)
Resumen:
IN A MOUSE STRAIN HIGHLY SUSCEPTIBLE TO DEVELOP
TH1 RESPONSES
Godoy, Gloria Janet1; Sánchez, Leonardo Rodolfo1; García,
Luciana2; Maldonado, Cristina2; Motrich, Rubén Darío1;
Virginia, Elena Rivero1
Dpto. de Bioquímica Clínica, Centro de Investigaciones
en Bioquímica Clínica e Inmunología (CIBICI)-CONICETUNC1
Instituto de Investigaciones en Ciencias de la Salud
(INICSA)-CONICET-UNC2
NOD mice are highly susceptible to chronic inflammation
disorders mostly mediated by Th1 responses. This increased susceptibility
has been thought to be related to defects in regulatory
T cells (Tregs). Recent findings evidenced that Tregs subsets are
heterogeneous and that different Tregs subsets able to specifically
regulate Th1, Th2 and Th17 immune responses would exist. In
this work, we developed a model of allergic asthma following established
immunization protocols with OVA plus aluminum salts in
NOD, C57BL/6 and Balb/c mice. We aimed to analyze if regulatory
defects observed in NOD mice were general or just restricted to
Th1 responses. After immunization, mice from every strain showed
clinical signs and symptoms of allergy when challenged with OVA
intranasally. Although increased leukocyte counts in broncoalveolar
lavage (BAL) were detected in both immunized NOD and
Balb/c mice, the highest levels were seen in Balb/c mice (p