RELEVANCE OF THE GALECTIN-1 (GAL1)-N-GLYCAN AXIS IN THE DEVELOPMENT OF SPONTANEOUS SIALADENITIS

MARTINEZ ALLO V; HAUK V; MORALES RM; STUPIRSKI JC; MARONNA E; PINTO N; PÉREZ LEIROS C ; RABINOVICH GA; TOSCANO MA

Mar del Plata

Congreso; LXII REUNIÓN ANUAL Sociedad Argentina de Inmunología; 2014

Gal1, an endogenous β-galactoside-binding protein, plays a critical role in immune cell homeostasis. Administration of recombinant Gal1 suppresses clinical signs of autoimmunity and chronic inflammation. However, the relevance of endogenous Gal1 in the development of spontaneous autoimmunity has not yet been reported. We have previously demonstrated that aged Gal1 deficient mice (Lgals1-/-) (~20 month) have increased weight and show augmented signs of inflammation in salivary glands compared to WT mice (P