INVESTIGADORES
DE CRISTOBAL Ricardo Ezequiel
congresos y reuniones científicas
Título:
Multidrug Resistance Pump AcrAB-TolC is Required for high-level TetA-mediated Tetracicline Resistance in Escherichia Coli.
Autor/es:
DE CRISTÓBAL, R. E.; VINCENT, P. A.; SALOMÓN, R. A.
Lugar:
Pinamar-Buenos Aires del 3 al 6 de Diciembre de 2005
Reunión:
Congreso; XLI Reunión Nacional SAIB.; 2005
Institución organizadora:
Sociedad Argentina de Investigaciones Bioquímicas y Biología Molecular
Resumen:
Escherichia coli tolC mutations severely reduced the high-level resistance to tetracycline afforded by Tn10 and plasmidencoded TetA pumps. Since mutational loss of the AcrAB multidrug efflux transporter had the same effect, it seems that tolC mutations act through inactivation of the AcrAB system These results are compatible with the hypothesis that the AcrAB pump is an important component in the development of high levels of resistance to tetracycline, perhaps by working in combination with TetA.
