Selection signatures in autochthonous Spanish cattle breeds using site frequency spectrum statistics

SEBASTIÁN MUNILLA; ALDEMAR GONZÁLEZ-RODRÍGUEZ; ELENA F. MOURESAN; JHON J. CAÑAS-ALVAREZ; JUAN ALTARRIBA; CLARA J. DÍAZ; ANTONIO MOLINA; PABLO MARTÍNEZ CAMBLOR; LUIS VARONA

Vancouver

Congreso; 10th World Congress on Genetics Applied to Livestock Production (WCGALP); 2014

WCGALP 2014 Organizing Committee and American Society of Animal Science

Autochthonous cattle breeds are a valuable reservoir of genetic diversity in Spain. Along their history, these breeds had been subjected to strong forces of differentiation and common selection. Based on genomewide SNP data from five different autochthonous breeds, in this study we computed two classical selection signatures statistics in a sliding windows scan along the genome. The statistics chosen were Tajima?s D and Fu and Li?s D*, both based on the folded site frequency spectrum. The onethousandth percentile value of the empirical distribution of each statistic was interpreted as a selection signature. Both regions of common signals among breeds and regions that show breed-specific signals were detected. An example spanning the region that harbors the Myostatin gene confirms the ability of the methods to detect different patterns of DNA variation among breeds in specific areas of the genome.