Preparation and evaluation of ciprofloxacin delivery from poly(3-hidroxybutirate) membranes

JOSÉ M. BERMUDEZ; ANALÍA I. ROMERO; MERCEDES VILLEGAS; M. FLORENCIA DIB ASHUR; MÓNICA L. PARENTIS; ELZA F. CASTRO VIDAURRE

Rio de Janiero

Simposio; II Simposio de Processos de Separacao com Membranas; 2013

Polymeric membranes are being investigated and used in pharmaceutical technology as controlled release systems to modulate body drug release. In this study we have evaluated the potential application of novel membranes constituted of poly (3-hydroxybutyrate) (PHB). PHB is an intracellular polyester synthesized by certain bacteria as a carbon and energy storage compound and shows promising applications in medicine due to its biodegradability and biocompatibility. Ciprofloxacine hydrochloride (Cipro) was the model drug used for the release studies. Cipro is a second-generation fluoroquinolone antibiotic, valued for its broad spectrum of activity and excellent tissue penetration. Composite membranes loaded with 5 (PHB-Cipro-5) and 15%wt Cipro (PHB-Cipro-15) were synthesized.