Memory rectivation beyond expression: Increments of HSP70 triggered by memory reactivation in the protocerebrum of Chasmagnathus

GABRIELA V. NIEVA; KARINA A. BARREIRO; ALEJANDRO DELORENZI

Huerta Grande, Córdoba

Congreso; XXVII Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; 2013

Sociedad Argentina de Investigación en Neurociencias

The reconsolidation hypothesis has challenged the traditional view of consolidation, including the notion that new memories are fixed and established.Previous studies of the group support the idea that there is dissociation between the mechanisms that mediate memory reactivation and the ones that mediate behavioral expression of memory. Our group has shown, in the LateralProtocerebrum (LP) in Chasmagnathus , neural changes induced by different training protocols correlate with memory persistence (evaluated as the capacity of memory to be reactivated and become labile) but not with the long-term expression of the reactivated memory. The central hypothesis of this Master´s Thesis project is that memory reactivation induces neuronal activity patterns in LP regardless memory expression. The goal is to show that memory built up after a weak training protocol can be reactivated even when long-term memory (LTM)formed by this training remains unexpressed. Using HSP 70 as a neuronal activity marker in LP we are evaluating whether unexpressed memories are reactivated,which will add evidence to the view that reactivation occurs independently of the expression of memory. Preliminary results show that memory reactivation of a consolidated but unexpressed memory induces, in small neuropils of the LP, an increase in HSP70 immunoreactivity.