INVESTIGADORES
HEREÑU Claudia Beatriz
congresos y reuniones científicas
Título:
CHARACTERIZATION OF COGNITIVE IMPAIRMENT IN TWO AGE GROUPS OF AGING RATS ON BARNES MAZE AND ITS MORFOLOGICAL CORRELATION IN DORSAL HIPPOCAMPUS
Autor/es:
MOREL G; ANDRESEN T; HEREÑU C; ZUCCOLILLI G; GOYA G.R.
Lugar:
Huerta Grande Córdoba
Reunión:
Congreso; XXVIII Congreso de la Sociedad Argentina de Investigación en Neurociencias & Reunión Satélite: ?Bases Neurales de la Conducta: Neuroetología y Neurobiología de la Memoria en el Cono Sur?; 2013
Resumen:
Aging is the primary risk factor associated with the increment of neurodegenerative diseases.
Human and animal studies have demonstrated age-related declines in learning and memory
abilities. The hippocampus is a medial temporal lobe structure that is necessary for the formation
of spatial memory. In previous studies, we observed a significant age-related reduction in
dopaminergic neuron loss in hypothalamic nucleus and the substantia nigra in the Sprague?Dawley
female rat (SD) which becomes more conspicuous at extreme ages.
In the current work we extended the studies on our model of aging SD female rat, focusing on
determining the extent of spatial memory impairment in two age group de senescent rats, 26
months old (OLD) and 29-32 months ( SENILE) and its histopatholical changes in dorsal
hippocampus. A 4-6 months old control young rats was employed. Age changes in spatial memory
performance were assessed on Barnes maze. The present study reveals differences between OLD
and SENILE rats in acquisition and spatial memory retention. Morphological analysis of dorsal
hippocampus shows a huge decrease (94-97 %) in DOUBLECORTIN neuron number in dentate
gyrus in both senescent groups and a reduce (40%) in VIMENTIN glial number in hilus only in
SENILE rats.
We concluded that SENILE rats present a major degree of cognitive impairment than OLD rats on
Barnes maze. Cognitive deficits in both senescent rats could be associated with a dramatic
reduction in neurogenesis