INVESTIGADORES
VILLAR Silvina Raquel
congresos y reuniones científicas
Título:
Adipokine alteration in patients with progressive forms of chronic Chagas disease
Autor/es:
FLORENCIA GONZALEZ, VILLAR SILVINA, JULIA MARQUEZ, MANARIN ROMINA, JUAN BELOSCAR, OSCAR BOTTASSO, ANA R. PÉREZ.
Lugar:
Los cocos- Córdoba
Reunión:
Congreso; LXI Reunión anual de la Sociedad Argenina de Inmunología.; 2013
Institución organizadora:
Sociedad Argenina de Inmunología
Resumen:
We previously reported immune-endocrine and metabolic
disturbances in patients with chronic Chagas disease. Althoughthe
pro-inflammatory adipokine leptin is associated
with the central regulation of energy metabolism, increasing evidence indicates
that leptinmay bealso involved in the
pathophysiology of heart failure. This issue in the context of chronic chagasic
myocarditis (CCM) is poorly understood.The aim of the present study was to
investigate plasma leptinlevels in T. cruzi infected individuals and their potential
relation with the immune-metabolic pattern and the degree of heart involvement.
Werecruited 74chagasic patients and 25 healthy individuals (Co). All subjects were
evaluated by electrocardiogram and chest X-ray and were classifiedintoasymptomatic
(Asy, n=24) or cardiac (Card, n=50) groups. Cardiac patients were also subclassified
into mild/moderate (MM, n=25) or severe (Sev, n=25) subjects. All individuals underwent
assessment of body mass index (BMI). Immune-metabolic
parameters likeleptin, IL-6, insulin, glucose and DHEAsplasma levels
were assessed.Leptin levels were significantly
higher in Cardiacand Asyrespect to Co subjects [ng/mL; mean±SEM, Co= 29±1.3;
Asy=33± 1.3 (p=0.006); Card=34±0.8 (p=0.04)], although Sev had lower values
than MM [MM=37±0.9; Sev=32±1.2, p=0.005]. BMI, glucose and IL-6 were increased
in Sev patients when compared to the Co group (p<0.05 in all cases) while
DHEAs was diminished (p<0.001).In chagasic subjects leptin levels correlated
positively with BMI (p<0.001), IL-6 (p<0.02) and insulin. In the overall
population, leptin correlated negatively with DHEAs (p<0.03).
Our results suggest that chronic chagasic individuals with
heart involvement develop marked immune-metabolic
disturbances, with leptinbeing likely to play role in CCM.