INICSA   23916
INSTITUTO DE INVESTIGACIONES EN CIENCIAS DE LA SALUD
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Body mass index and sperm quality: effects of overweight and underweight.
Autor/es:
MARTINI AC; TISSERA A; VINCENTI LM; ESTOFÁN D; BELTRAMONE F; SAD J; RUIZ RD; FIOL DE CUNEO M; MOLINA R
Lugar:
Sevilla
Reunión:
Congreso; V Congreso Internacional de Medicina Reproductiva.; 2013
Institución organizadora:
Sociedad Europea de Reproducción
Resumen:
We
previously reported a negative association between body mass index (BMI) and sperm
motility and seminal alpha-glucosidase concentration (NAG), suggesting that
epididymis may be a target organ for weight-linked alterations. In this study,
we analyzed a possible association between BMI and semen quality in 4876
patients with no genitourinary diseases or toxin exposure, including
morbidly-obese and underweight patients. We performed multivariate regression analysis using BMI, age
and abstinence as independent variables and demonstrated that BMI was inversely
and significantly associated with semen volume, total sperm count, motility and
NAG (slopes: -0.01, -1.33, -0.18, -0.75; p<0.05); in addition, we found a
significant negative association between BMI and viability, morphology and
HOST.
Furthermore,
we randomly selected a similar group of patients and evaluated the seminal
characteristics of underweight (UW=BMI<20, n=45), normal (N=20≤BMI<25,
n=50), overweight (OW=25≤BMI<30, n=50), obese (O=30≤BMI<40, n=50) and
morbidly-obese (MO=BMI>40, n=57) patients, performing MANCOVA test with age
and abstinence as co-variables. We found that not only MO, but also UW patients
had spermogram impairments, reaching statistical significance in sperm
concentration (UW=42.7±6.0, N=54.7±5.5, OW=59.1±7.5, O=54.4±6.1 and
MO=37.9±4.9; p<0.05 OW and O vs UW and MO; p<0.05 N vs MO) and total
sperm count (UW=103.3±11.4, N=161.3±19.0, OW=166.5±20.0, O=149.1±17.2 and
MO=121.5±20.6; p<0.05 N, OW and O vs UW; p<0.05 OW vs MO). In
conclusion, although the increase of BMI is negatively associated with semen
quality, underweight also constitutes a risk factor for infertility. Since
sperm density, motility and NAG are markers of the epididymal function, these
new results support our original hypothesis.