INVESTIGADORES
QUEVEDO Mario Alfredo
congresos y reuniones científicas
Título:
Comparison of antimicrobial activity and stability study of doxycycline hyclate and its inclusion complex development of a new powerful compound
Autor/es:
KOGAWA, A.C.; ZOPPI, A.; QUEVEDO, M.A.; LONGHI, M.R.; NUNES SALGADO, H.R.
Lugar:
Araraquara
Reunión:
Congreso; II International symposium on drug discovery; 2011
Institución organizadora:
Comité Organizador del II International symposium on drug discovery
Resumen:
Doxycycline
hyclate (DOX), a broad-spectrum antibiotic, is part of the Unified Health
System in Brazil, which is free-distributed to all by prescription.
Unfortunately 1DOX is quite susceptible to light. 2A
commonly applied approach to increase the stability of drugs is the formation
of complexes with β-cyclodextrin (βCD). Despite the growing number of studies using cyclodextrins (CDs) in the
formation of IC, this approach would not work to isolate the drug from the
medium in which it is placed, but the external environment, because of the
characteristic of DOX to be photosensitive and thus to compare their
antimicrobial activity.
After thermal and spectroscopic analysis to
confirming the inclusion of DOX in βCD and showed how it is complexed, we carried out the development and validation of microbiological turbidimetric method for the
quantification of DOX.
The aim of
this work was to compare, using the
turbidimetric microbiological method, both the antimicrobial activity of the IC
with DOX as the antimicrobial activity between them after exposure to UV light.