INVESTIGADORES
LOCATELLI Fernando Federico
congresos y reuniones científicas
Título:
The Honey bee as a model to study the interaction between the nervous and the immune system
Autor/es:
KLAPPEBACH MARTIN; LOCATELLI FERNANDO; DEPINO AMAICHA
Lugar:
Huerta Grande, Cordoba
Reunión:
Congreso; Congreso SAN 2013; 2013
Institución organizadora:
Sociedad Argentina de Investigaciones en Neurociencias
Resumen:
The
Honey bee as a model to study the interaction between the nervous and the
immune system
Martin Klappenbach1,
Fernando Locatelli1 and Amaicha Depino2
1. Laboratorio de Neurobiología de la Memoria. FCEN-UBA. IFIBYNE-CONICET
2. Laboratorio de Neurobiología del Autismo. FCEN-UBA.
IFIBYNE-CONICET
Proper response to infections is a
critical issue for all animals. During last years, it has been established that
although the immune system is the principal responsible for this task, the
nervous system has a relevant role too. How these two systems interact is an
important question in the field of immunology and neurosciences.
In this work, we demonstrated that
the administration of an inflammatory molecule (bacterial lipopolysaccharides,
LPS) into the thorax of bees causes a reduction in the locomotor activity from
50 min until, at least, 130 min after the injection. In addition, honey bees
showed a loss of appetite both 60 and 90 min after the administration of LPS.
24 hours after injection animals recovered the appetite, confirming an acute
modulation of behavior during inflammation. These results show that honey bees
exhibit a sickness behavior, and allow us to use it as model to study how the
immune and nervous system interact.
We will analyze two molecular
pathways that we consider candidates for the regulation of the honey bee?s
behavior. We will examine the role of eicosanoids, reported as principal
mediators of the immune response in insects. We propose also that there could
exist an octopaminergic pathway activated in response to inflammation. The role
of octopamine as neurohormone and neurotransmitter leads us to propose this
amine as a key factor in the interaction of the nervous and the immune system.
Thus, further studies performed in
honey bees could help us to increase the knowledge about the interaction
between the nervous and the immune system.