?Memory neuropharmacology of consolidation and reconsolidation?

BOCCIA MM

Huerta Grande, Córdoba

Simposio; XXVIII CONGRESO ANUAL DE LA SOCIEDAD ARGENTINA DE INVESTIGACION EN NEUROCIENCIAS & Reunión satélite sobre Neurobiología del Comportamiento: ?NeuroetologÍa y Neurobiología de la Memoria en el cono sur? Un homenaje a Héctor Maldonado; 2013

Sociedad Argentina de Neurociencias

Experimental and clinical evidence has given support to the hypothesis thatcerebral acetylcholine plays a role in mnemonic phenomena. Thus, central orsystemic administration of anticholinergic drugs or lesions of the cholinergicsystem cause memory impairment while drugs that enhance cholinergic activityimprove memory. Most of these studies have dealt with the acquisition andconsolidation of memory and less attention has been paid to the retrieval andextinction processes. Several reports suggest that when a well ? consolidatedmemory is recalled it becomes sensitive to disruption to the same treatments thataffect consolidation. This new window of susceptibility is now referred asreconsolidation. In the present work it will be presented experimental evidencesthat suggest a possible role of central cholinergic mechanisms not only on memoryconsolidation, but also in memory processes that take place after memory recall.