Dissociating long term memory storage from expression: an optophysiology approach in the crab Chasmagnathus.

FRANCISCO JAVIER MAZA, FERNANDO LOCATELLI, ALEJANDRO DELORENZI

Cordoba

Congreso; SAN- Taller Argentino de Neurociencias 2012; 2012

SAN

Cognition, Behavior, and MemoryPoster Number 95 / Session IIIDissociating long term memory storage from expression: anoptophysiology approach in the crab Chasmagnathus.Francisco Javier Maza, Fernando Locatelli, Alejandro DelorenziLaboratorio de Neurobiología de la Memoria. Departamento de Fisiología,Biología Molecular y Celular, FCEN, UBA. IFIByNE-CONICET.fjmaza@hotmail.comThe canonic view for amnesias suggests storage or, alternatively, retrievalimpairments. However, results in our group have shown that some experimentalamnesias cannot be explained by these views. Instead, they are explained as adeficit in memory expression (i.e. the memory is stored and can be reactivatedbut it’s not expressed). Here we introduce an approach in achieving neuralrelated evidence for this Hypothesis: we propose that memory storage andexpression are different attributes of memories that could be based in differentneural interactions. We have made in vivo calcium imaging inChasmagnathus´s Lateral Protocerebrum (a neuropil proposed to be involved insensory integration and memory process) and we analyzed whether theinduced changes in neural activity correlate with memory expression (duringtraining and 30 minutes after). Then, we tested whether two kind of amnesictreatments, one proposed to interfere with the expression of memories and theother proposed to interfere with memory storage, differentially affect the plasticchanges induced by the training protocol. Our results suggest that the changesinduced in the neural networks of the Lateral Protocerebrum reflect, at shortterm, long term memory storage but not long term memory expression