INVESTIGADORES
LOCATELLI Fernando Federico
congresos y reuniones científicas
Título:
Dissociating long term memory storage from expression: an optophysiology approach in the crab Chasmagnathus
Autor/es:
MAZA FRANCISCO; LOCATELLI FERNANDO; DELORENZI ALEJANDRO
Lugar:
Huerta Grande, Cordoba
Reunión:
Congreso; Sociedad Argentina de Neurociencias 2012; 2012
Institución organizadora:
Sociedad Argentina de Neurociencias
Resumen:
The canonic
view for amnesias suggests storage or, alternatively, retrieval
impairments. However, results in our
group have shown that some experimental amnesias cannot be explained by these
views. Instead, they are explained as a deficit in memory expression (i.e. the
memory is stored and can be reactivated but it?s not expressed). Here we
introduce an approach in achieving neural related evidence for this Hypothesis:
we propose that memory storage and expression are different attributes of
memories that could be based in different neural interactions. We have made in
vivo calcium imaging in Chasmagnathus´s Lateral Protocerebrum (a neuropil
proposed to be involved in sensory integration and memory process) and we analyzed
whether the induced changes in neural activity correlate with memory expression
(during training and 30 minutes after).
Then, we tested whether two kind of amnesic treatments, one proposed to
interfere with the expression of memories and the other proposed to interfere
with memory storage, differentially affect the plastic changes induced by the
training protocol. Our results suggest that the changes induced in the neural
networks of the Lateral Protocerebrum reflect, at short term, long term memory
storage but not long term memory expression.