INVESTIGADORES
CREMASCHI Graciela Alicia
congresos y reuniones científicas
Título:
Antidepressant treatment prevents chronic stress induced impairment of T-cell immunity and enhancement of tumor growth.
Autor/es:
FRICK L; KLECHA A; CREMASCHI G; GENARO A
Lugar:
Córdoba, Argentina
Reunión:
Congreso; XXXVIII Reunión Anual de la SAFE; 2006
Institución organizadora:
Sociedad Argentina de Farmacología Experimental
Resumen:
Chronic
stress is involved in the onset of specific psychiatric diseases such as major
depression. Stress also affects the immune response. T-cell mediated immunity
is a key component in solid tumor rejection. Depression of antitumoral immunity
induced by stress could contribute to tumor growth, and antidepressant
treatment could prevent this effect. We studied the effects of chronic stress
and antidepressant treatment in the immune response as well as in the evolution
of neoplasic pathology. BALB/c mice were subjected to chronic restraint stress
(CRS), a well validated model of depression. Lymphocyte proliferation to a T
selective mitogen was evaluated by [3H]-thymidine incorporation. A
significant reduction in T cell proliferation was observed in CRS animals. CRS
and normal syngeneic mice were subcutaneously injected with 1x106
LBC T lymphoma cells to generate a solid tumor. Measures of tumor volume
indicated that growth is increased in CRS mice. To test if these effects are
reversed by antidepressant treatment, CRS mice were concomitantly treated with
15 mg/kg fluoxetine. Fluoxetine prevented T cell impaired proliferation in CRS
animals. Moreover, these animals showed the same lymphoma evolution than their
normal counterparts. These results suggest that stress-related depressive state
promotes tumor growth by depressing T-cell mediated immunity and that chronic
antidepressant treatment prevents enhanced tumor evolution by reversing T-cell
impairment.