INTEC   05402
INSTITUTO DE DESARROLLO TECNOLOGICO PARA LA INDUSTRIA QUIMICA
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Dynamic Analysis of a Single-Nephron Model due to Changes in Efferent Blood Viscosity
Autor/es:
ESPINEL, ANDREA; P. S. RIVADENEIRA; V. COSTANZA; AMORENA, CARLOS
Lugar:
Antalya
Reunión:
Simposio; 4th Interdisciplinary Symposium on Chaos and Complex Systems; 2012
Institución organizadora:
Ýstanbul Kültür Üniversitesi
Resumen:
In this paper, a mathematical model of the dynamics of a single-nephron
function relating glomerulo-tubular balance, tubule-glomerular feedback, and peritubular
blood viscosity is developed. Based upon experimental data, the model
shows that complex behaviors of the nephron can be modulated by changes in the
efferent arteriole blood viscosity. The main hypothesis is that the reabsorbed mass
flow is modulated by the hematocrit of the efferent arteriole, in addition to the Starling
forces. From a mathematical perspective, these behaviors can be explained by a
bifurcation diagram analysis where the efferent blood viscosity is taken as the bifurcation
parameter. This analytical description allows to predict changes in proximal
convoluted tubule reabsorption, following changes in peritubular capillary viscosity
generated by periodic changes in the glomerular filtration rate. Thus, the model
links the tubule-glomerular feedback with the glomerular tubular balance.