Arterial Stiffness and Endothelial Function in Obese Children and Adolescents

PERAL DE BRUNO M; NEGRETE ALEJANDRO; CLAUDIO JOO TURONI; SALAS NICOLÁS,; BRUNO MARIA E; BAZAN DE CASELLA CRISTINA

Montevideo

Congreso; XXIII Reunion Anual de la Latin American Society of Pediatric Endocrinology; 2012

Latin American Society of Pediatric Endocrinology

Arterial Stiffness and Endothelial Function in Obese Children and Adolescents Peral de Bruno, María1(*); Negrete, Alejandro1; Joo Turoni, Claudio1; Salas, Nicolas1; Bruno, María Elisa2; Bazán de Casella, María Cristina3 1Facultad de Medicina – Universidad Nacional de Tucuman | (*) Argentina; 2Sistema Provincial de Salud (SIPROSA) Tucuman; 3Hospital del Niño Jesus- SIPROSA – Tucuman Vascular function is impaired in hypertension, diabetes, metabolic syndrome (MS) and obesity. In the pediatric population there are few studies about the endothelial function (EF) and arterial stiffness (AS). Objective: To determine vascular function assessing EF and AS in obese children and adolescents and its relation to cardiovascular risk factors. Methods: We studied obese boys (BMI ≥ percentile of 97) of the endocrinology outpatient service of the Hospital del Niño Jesús (Hosp) with no history of prior disease (n=25, age: 12.6±0.5 years). We measured anthropometric parameters, fat mass (FM), blood pressure and laboratory data. The EF was assessed by reactive hyperemia and AS by the pulse wave. Data were compared with non-obese boys from the Hosp or Avellaneda school – Monteros (n=13, 13.8±0.7 years). Results: The obese showed higher FM, waist circumference (WC), insulinemia and HOMA index. BMI was correlated with FM (R2: 0.5844, p