Pneumonia associated to Human Bocavirus1 infection in infants from Cordoba, Argentina

EGUIZÁBAL LETICIA; MORENO LAURA; GHIETTO LUCÍA; BARRETO CLAUDIA; POLO CONSTANZA; FERRERYRA SOAJE PATRICIA; MARQUES INÉS; MOSCA LILIANA; CÁMARA JORGE; CAMARA ALICIA; QUIROGA DANIEL; ADAMO M. PILAR

Daytona Beach, Florida, USA

Simposio; 28th Clinical Virology Symposium; 2012

Panamerican Society for Clinical Virology

Introduction: Human bocavirus (HBoV1), identified in 2005, has been associated with symptoms of upper and lower acute respiratory infection (ARI) in children, with prevalence ranging from 1.3 to 33%, depending on the series. The purpose of this study was to detect HBoV1 in infants with ARI at Cordoba and to describe the positive cases without viral coinfection. Methods and results: The study was prospective and observational. Infants (0 to 2 years old) admitted with ARI at the Children´s Hospital of Cordoba from January through December 2011 were included, after obtaining informed consent signed by parents or tutors. In 222 patients tested 15 (6.8%) were positive for HBoV1 and coinfection with other common respiratory virus or bacteria was detected in 8 patients [5/8 had coinfection with respiratory sincicial virus (RSV), 1 with influenza A, 1 with parainfluenza 3, and 1 witn Bordetella pertussis]. The average age of HBoV1+ patients without evident coinfection was 3.3 ± 0.3 months (range: 2 ? 12 months). The prodrome among these 7 HBoV1+ patients extended over 3.7 ± 3.4 days and they remain hospitalized an average of 6.2 ± 2.5 days. Among 8 patients in whom HBoV1 was detected in coinfection with other respiratory agent, the prodrome spanned 2.5 ± 2.3 days and the average period of hospitalization was 9.0 ± 4.3 days, but the differences compared with HBoV single infections were not statistically significant (p = 0.083 for ?days of hospitalization? and p = 0.246 for ?prodrome?). Four out of 7 patients with HBoV1 single infection had pneumonia, 1 had bronchiolitis, 1 had apnea and 1 had suspected sepsis; none was hospitalized in intensive care unit, but 6 required oxygen therapy, 6 were treated with bronchodilators and all 7 received antibiotics. All 15 HBoV1+ patients recovered without complications. Conclusions: The prevalence of HBoV1 in infants hospitalized with ARI in Córdoba during 2011 was 6.8%. Fifty-three percent of the cases occurred in coinfection with other respiratory agent (mainly with RSV). The predominant diagnosis was pneumonia but severe complications were not registered.