CONICET | Buscador de Institutos y Recursos Humanos

Urinary Tract Tumors (UTT) can be influenced by diet, since urinary tract surfaces are in close contact with many potentially mutagenic compounds contained in foods and their metabolites before being excreted through urine. Epidemiological and laboratory research have found that artificial sweetener (AS) could be associated with this disease. Objective: The purpose of this investigation was to analyse the role of the habitual use of the most common AS in the development of UTT. Methods: In this this case-control study conducted in Cordoba (Argentina) between 1999 and 2006, all subjects were interviewed using a FFQ previously validated - about their use of AS in addition to their exposure to a number of other known or suspected risk factors for UTT. 197 patients with histologically confirmed UTT of transitional varieties, and 397 controls with acute, non-neoplastic, and non-urinary tract diseases, admitted to the same hospitals, were included. To assess the strength of the association between AS use and the risk of UTT, odds ratios (OR) and their 95% confidence intervals (CI) were computed using multiple logistic regression. Results: the observations on AS consumption deal exclusively with those who used them as an additive in infusions (tea, coffee, and mate). Fifty-one UTT patients (26%) and eighty-seven controls (22%) had ever used AS. The risk of UTT was significantly increased in long-term (>10 years) AS users compared with never-AS users. The OR for long-term group consumers was 2.175 (95% CI: 1,216-3.888) and for short-term, 1,103 (95% CI: 0.608-2.002), after adjustment for age, gender, BMI, social status and years of tobacco use. This study shows that regular use for 10 years or more of AS was associated with UTT, for the population studied.

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