EVALUATION OF COSMETIC AND PHARMACEUTICAL PRODUCTS MADE IN THE FRAMEWORK OF THE IMPLEMENTATION OF A SYSTEM OF PERSONALIZED EDUCATION

ARIAS, M.E.;; SESTO CABRAL, M.E ;; NIEVA MORENO, M.I.;; GÓMEZ MORTON, T.;; ORDÓÑEZ, A.;; GÓMEZ, J.D.

Cordoba-Capital

Congreso; I Reunion Internacional de Ciencias Farmaceuticas RICiFA; 2010

Facultad de Ciencias Quimicas- UNC

Introduction: In order to evaluate the performance in the laboratory of advanced students of Pharmacy, teachers of Pharmaceutical Technology II, carried out controls of pharmacotechnical stability of formulations elaborated during the practical Design of a Pharmaceutical Formulation. Vegetal plants material was chosen between species with recognized therapeutic activity, and assigned to different groups of students. The aim was to develop a pharmaceutical or cosmetic product efficient, stable and secure. The preformulation study, implementation of good manufacturing practices (GMP), formulation and development of pharmaceutical products for topical use, was considered. The quality assurance thereof, following the norms established by Argentina Pharmacopoeia VII edition was evaluated. This work was developed within the framework of the implementation of the pedagogy method known as Personalized System of Instruction (PIS). These controls were conducted as a part of the evaluation process of the method implemented by the laboratory since 2007. In this paper the analysis of results as a positive conclusion about didactic resource implemented is well detailed. Materials and Methods: The quality of pharmaceutical dosage forms and / or cosmetics designed and development for topical application by students was evaluated. Stability assays: Organoleptic Characteristics (color and smell); Uniformity (macroscopic and microscopic), optical microscope and magnifying glass; pH: with a pHmeter Broadley James Corporation; Rheological Behavior: apparent viscosity Brookfield rotary viscometer RVF; Extensibility: extensometer; Heat Resistance: dry oven brand FAH (Industria Argentina); Water Content (Determination of loss on drying weight): dry oven brand FAH (Industria Argentina), Mechanical Stress: lab centrifuge; Short Term Stability assay or Accelerated Aging: dry oven brand FAH, freezer. Microbiological assay: The count of total CFU was made and media culture for aerobials was used. Individually analysis, physicochemical and microbiological test were performed according to the specific recommendations of Pharmacopeia. Results: The sensory characteristics of all pharmaceutical dosage forms kept uniform. Most topical products showed pH values that are within the optimum range for the skin (5 to 6) and not show significant change during the test period was noticed. In terms of its rheological properties non-Newtonian pseudoplastic flow, with good degree of structural recovery, was found in all the products as well as stable against thermal and mechanical stress. No significant loss of weight in normal conditions of pressure and temperature was observed. The samples remained physically, chemically and microbiologically stable during the test period. Conclusions: From the results analyzed can be concluded that students correctly applied the rules of GMP, worked applying and relating theoretical and practical knowledge?s acquired during their studies. This experience enriches and encourages to the future professionals to face the challenges of the pharmaceutical profession and solve them wisely. The self-assessment was made by the teaching team and determined that the present methodology is appropriated as a method of instruction, and will be adopted as a teaching method of choice from now on.