COMPUTATIONAL MODELLING OF CORNEAL BIOMECHANICS FOR DIAGNOSIS AND TREATMENT WITH MICRODEVICES.

FABIO A GUARNIERI

Buenos Aires

Congreso; International Congress of Eye Research; 2006

International Society of Eye Research

Clinical features of keratoconus, like ectasia and corneal thinning, can be explained by a biomechanical hypothesis where a lack of cohesion between the collagen fibrils and the extracellular matrix. In this work a computational model is presented which introduce a new biomechanical model of keratoconus and others corneal disorders. The model is developed using the Finite Element Method (FEM). Each lamella is modelled as an nonlinear hyperelastic anisotropic material where the collagen fibers, the extracellular matrix and the proteoglycan crosslinking  are taken into account. Regional differences like anterior-posterior interweaving and preferred orientations of lamellae are taken into account. Simulations of corneal interaction with intrastromal rings surgery for keratoconus treatment and contact lens microsensor for intraocular pressure measurement will be presented.