CEFYBO   02669
CENTRO DE ESTUDIOS FARMACOLOGICOS Y BOTANICOS
Unidad Ejecutora - UE
congresos y reuniones científicas
Título:
Neuroprotective effects of brief ischemia pulses in an experimental model glaucoma
Autor/es:
BELFORTE, NA; SANDE, PH; DE ZAVALÍA NURIA; FERNANDEZ, DC; SILBERMAN, D.M; CHIANELLI, MS; ROSENSTEIN, RE
Lugar:
Huerta Grande, Córdoba
Reunión:
Congreso; XXVI Congreso Anual de la Sociedad Argentina de Investigación en Neurociencias; 2011
Institución organizadora:
Sociedad Argentina de Investigación en Neurociencias
Resumen:
Glaucoma is a leading
cause of acquired blindness which may involve an ischemic-like insult to
retinal ganglion cells and optic nerve head (ONH). We investigated the effect
of a weekly application of brief ischemia pulses (ischemic conditioning) on the
retinal damage induced by experimental glaucoma. Glaucoma was induced by weekly
injections of chondroitin sulfate (CS) in the rat eye anterior chamber. Retinal
ischemia was induced by increasing intraocular pressure to 120 mmHg for 5 min;
this maneuver started after 6 weekly injections of vehicle or CS and was weekly
repeated in one eye, while the contralateral eye was submitted to a sham
procedure. Glaucoma was evaluated in terms of: intraocular pressure (IOP),
retinal and visual pathway function (electroretinogram (ERG), and visual evoked
potentials (VEPs)) and histology of the retina and ONH. Retinal thiobarbituric
acid substances levels were assessed as an index of lipid peroxidation.
Ischemic conditioning significantly preserved ERG, VEPs, retinal and ONH
structure from glaucomatous damage, without changes in IOP. Moreover, ischemia
pulses abrogated the increase in lipid peroxidation induced by CS. These
results suggest that induction of ischemic tolerance could constitute a new
therapeutic strategy in glaucoma treatment.