ALLOPREGNANOLONE PREVENTS MEMORY IMPAIRMENT THROUGH HIPPOCAMPAL SEROTONERGIC SYSTEM.

ESCUDERO C.; GARCÍA S.; CHÁVEZ MC.; BAZZOCCHINI V.; CASAS S.; GIULIANI F.; YUNES R.; CABRERA R.

Huerta Grande -Córdoba

Congreso; XXXVI Reunión Anual de la Sociedad Argentina de Neurociencias; 2011

SAN

Learning and memory processes may be influenced by estrogen (E) and progesterone (P) and neurosteriods, such as Allopregnanolone (Allo). In previous work, we demonstrated that Allo improves memory in OVX female rats infused (s.c) with E and P on inhibitory avoidance task (IA task). Serotonine (5HT) is a neurotransmitter related with memory processes. Here we investigated the effect of Allo over 5HT release in hippocampus. K+ evoked [3H]-5HT release of dorsal hippocampus slices of the different groups was carried out by superfusion method. Different treatments were: control (OVX-EP-Vehicle), OVX-EP-Allo and OVX-EP-Allo-8OHDPAT (5TH agonist). All groups were trained in IA task and, after 24-h intertrial delay; SD (step down) latency was tested. Results were analyzed by ANOVA 1 and Turkey’s post-test (p