INVESTIGADORES
MERESMAN Gabriela Fabiana
congresos y reuniones científicas
Título:
GALECTIN-1 ROLE IN ENDOMETRIOSIS PATHOPHYSIOLOGY
Autor/es:
BASTON JI; RICCI A; BILOTAS M; OLIVARES C; RABINOVICH G; BARAÑAO RI; MERESMAN G
Reunión:
Congreso; XII Jornadas anuales de la Sociedad Argentina de Biología (SAB); 2010
Resumen:
Endometriosis (EDT) is characterized by the
ectopically occurrence
of endometrial tissue reassembled in peritoneal or ovarian lesions.
EDT is a common benign illness that affects 10% of women in
reproductive age and its pathogenesis still remains unknown.
Galectin-1 belongs to a family of endogenous lectins and has binding-
affinity for multiple N-acetyllactosamine residues comprised
on N- and O- glycans. This lectin is a key immunoregulatory, proangiogenic
and growth-promoting factor in tumors. Data have not
been reported on the role of Gal-1 in EDT etiology yet. Our hypothesis
is that Gal-1 expression in endometriotic lesions improves
endometrial cell survival and growth at the ectopic sites. In this
study, we induced endometriotic lesions in female C57BL/6 wildtype
and Gal-1 knock-out (Lgals1-/-) mice. Four weeks later the
number and size of lesions was recorded and the cell proliferation
and % vascularized area in the lesions were evaluated by
immunohystochemistry for PCNA and CD34 markers respectively.
Results show a significant decrease of lesion size (p<0.05), proliferating
cell-rate (p<0.05) and vascularized area (p<0.01) in Gal-1
null mice. These results suggest that Gal-1 favours EDT development
promoting ectopic endometrial cell proliferation and lesion
vasculature expansion.