Novel localization of NF-kappa B in mouse forebrain synaptic terminals. Activation dynamics during memory consolidation.

LAGOS M.; BOCCIA MM; BLAKE MG; CORBI N; PASSANANTI C

HUERTA GRANDE, CÓRDOBA

Congreso;  II RCN II Reunión Conjunta de Neurociencias – Second Joint Meeting of the Argentine Society for Neuroscience and the Argentine Workshop in Neuroscience.; 2010

SOCIEDAD ARGENTINA DE NEUROCIENCIAS

NF-kappa B activation has recently been shown to be necessary for long-term memory consolidation and reconsolidation, in the inhibitory avoidance learning in the mouse hippocampus. NF-kappa B is activated in the cell nucleus in specifictemporal windows in both consolidation and reconsolidation. Previous results showed that the transcription factor is also present in synaptic terminals. This work focuses in the dynamics of its synaptic activation during consolidation, in two different synaptic localizations: soluble in the synaptic content and, in a pool describedfor the first time in this work, bound to the cell membrane. The function of this novel localization is discussed.