INVESTIGADORES
TURJANSKI Pablo Guillermo
congresos y reuniones científicas
Título:
Mathematical-numerical modeling of glioma evolution
Autor/es:
C. SUAREZ; P. TURJANSKI; G. MARSHALL
Lugar:
Córdoba
Reunión:
Congreso; 2do Congreso Argentino de Bioinformática y Biología Computacional; 2011
Institución organizadora:
Asociación Argentina de Bioinformática y Biología Computacional
Resumen:
Gliomas, derived from glial cells or their precursors, are the most common primary brain tumors. Up tonow, they are almost incurable, mainly due to their great invasiveness capacity. Most of present imagingtechnology used in brain tumor detection (nuclear magnetic resonance and computed tomography), isnot yet able to detect the real extension of tumor infiltration. This is one of the causes of the highrecurrence of tumor growth observed after surgery and the final treatment failure. Here we present amathematical model, based in a previous one from Swanson, that describes the three dimensionalgrowth and invasiveness of a glioma incide a human brain and its possible reduction/elimination by aneventual treatment (figure 1). The model considers a net proliferation rate, described by a logisticequation, and a net invasion rate, described by the Fick’s law, differing for grey and white matter. Aninitial state with only cellular proliferation (benign tumor) and an advanced state where cellular infiltrationbegins (malignization) are considered. The survival time is estimated on the basis of tumor size and thetype of brain structures affected. The mathematical model was approximated with finite differences andimplemented in Matlab. The domain is based on a series of digitized images of brain slices developed bythe Neurological Institute of Montreal, covering the whole human brain with a spatial resolution of 1 mm3.At present we are concerned with the clinic validation of the model with the aim of employing it as apredictive tool, complementary with other techniques, when determining the risk/benefit relationship of agiven treatment in a patient-specific manner.