?Neuroendocrine Regulation of Sodium Intake Induced By Peritoneal Diálisis?.

A. GODINO; L. MARGATHO; A. GIUSTI-PAIVA; J. ANTUNES-RODRIGUES; L. VIVAS

Pinamar, Argentina

Congreso; Congreso Conjunto: X PABMB Congress- Panamerican Association For Biochemistry And Molecular Biology, SAIB, XLI Annual Meeting, Sociedad Argentina De Investigación En Bioquímica Y Biología Molecular - SAN, XX Annual Meeting -Sociedad Argentina De Neuroquím; 2005

NEUROENDOCRINE REGULATION OF SODIUM INTAKE INDUCED BY PERITONEAL DIALYSIS ¹Godino, Andrea; ²Margatho, Lisandra; ²Giusti-Paiva, Alexandre; ²Antunes-Rodrigues, José y ¹Vivas, Laura.  ¹INIMEC, Cba., Argentina. ²Depto de fisiología, Facultade Medicina, Riberao Preto, Brasil.  agodino@immf.uncor.edu The goal of the present work was to study the neuroendocrine response before and after salt-induced ingestion stimulated by peritoneal dialysis (PD). Adult male Albino rats were sodium depleted by peritoneal dialysis. Twenty-four hours after PD or PD sham, the groups were designed as control (PD sham) with no access to water and 2% NaCl (C-NA), PD with no access to water and 2% NaCl (PD-NA), control (PD sham) with access to water and 2% NaCl (C-A), and PD with access to water and 2% NaCl (PD-A).The animals were decapitated and bled before and after test. The trunk blood was collected and plasma levels of ANP and OT were measured by radioimmunoassay as previously described by Godino et al. (2005). Compared with the others groups PD-A showed an increase in the plasma levels of ANP and OT (p<0.05). Moreover, the plasma level of ANP in the PD-A group had a higher significant increase compared to PD-NA (p<0.001). Our data indicate that plasma OT and ANP are released during the satiety process of sodium appetite. ANP also participate during the sodium appetitive phase. This evidence suggest that sodium body status modulates the OT and ANP release to blood circulation.   Supported by CONICET and CNPq.