Controlled drug release system: cyclophosphamide delivery contained in LPSBA- 15 functionalized with tert-butylamine

JULIANA M. JUÁREZ; JORGELINA CUSSA; OSCAR A. ANUNZIATA; MARCOS B. GÓMEZ COSTA

Cancún

Congreso; XXXI International Materials Research Congress (IMRC 2023); 2023

IMRC

Controlled drug administration systems can keepthe level of drugs in specific locations in theorganism with low toxicity and abovethe optimal level. We suggest the LP-SBA-15 material as aauspicious new hostfor drug delivery systems because of its low toxicity high biocompatibility andinvivo biodegradability. LP-SBA-15 materials were synthesized and functionalized using0-15-30% of tertbutylamine(TBA) and used as effective drug delivery systems.The anticancer drug Cyclophosphamide (CP) is analkylating compound which is a phosphoramidederivative and is habitually usedin autoimmune diseases. Reactive oxygen species production hasbeen related to themechanism of CP-induced cell death or tumor cell killing. The activatedmetabolites of CPare released in both healthy and tumor tissues and destroy the cellular DNAandproteins as well as mitochondrial and lysosomal membranes. CP was loaded intothenanomaterial of the transporters and characterized by XRD, FTIR, TGA, TEM and texture, determiningtheadsorption capacity and its release.The release of the drug was studied for eachmaterial by simulating the physiological conditions andsubmerging thecomposite, at 37 °C with constant stirring, in a HCl solution (0.1 M) for thefirst twohours and in Buffer solution pH = 7 the following hours to simulate theconditions of the organism.Release experiment were conducted to determinethe requisite efficacy of treatment. The study wasperformed by UV-Visspectrophotometry to evaluate the amount of CP released. The mechanism ofdrugrelease the LP-SBA-15 matrix was evaluated by adjusting the experimentaldata, being the Ritger-Peppas.The promising results we obtained for the controlledrelease of the drug in a controlled manner using the new material, reaching a quickinitial release rate and maintaining a constant rate at highmoments, allow usto keep the concentration of the drug in the therapeutic efficacy range,applying itto a great extent to the treatment of diseases that require a rapidresponse. Lastly, it was suggestedthat the LP-SBA-15 nanomaterialfunctionalized with 15% TBA was the most desirable system due to they had adequateamounts of both drug loading and release.