237. SECRETORY LEUKOCYTE PROTEASE INHIBITOR (SLPI), VITAMINA D (VD) AND OBESITY IN ELDER WOMEN. PRELIMINARY STUDY

SEIJO, MARIANA; AMBROSSI, N; BONANNO, MARINA SOLEDAD; ZENI CORONEL, ESTEFANÍA MAGALÍ; CHULUYAN, E; ZENI, SUSANA NOEMÍ; OLIVERI, BEATRIZ

Mar del Plata

Congreso; Reunión Conjunta SAIC, SAB, AAFE, AACYTAL 2023; 2023

SAIC, SAB, AAFE, AACYTAL

Besides its role on bone calcium homeostasis, VD has anti-inflammatory actions, increasing antimicrobial peptides expression as cathelicidin. Adequacy in VD demonstrated anti-inflammatory activity while low 25hydroxyVD (25OHD) levels were linked to obesity.SLPI is a highly cationic non-glycosylated serine protease peptide with antimicrobial and anti-inflammatory activity that, among other function lowers the expression of inflammatory cytokines as TNFa and IL1b. Growing evidences suggest that there is a negative correlation between SLPI and risk factors of atherosclerosis, such as obesity and inflammation. Objective: to evaluate 25OHD correlation with SLPI in obesity a condition of chronic inflammation. Obese women (n=32), 69±6 years, without other conditions or medications that could affect inflammatory status (infectious diseases in the last 3 months; autoimmune diseases; renal insufficiency [i.e., creatinine clearance