Zinc supplementation during postnatal growth: is it beneficial for reducing cardiovascular and metabolic effects associated with metabolic syndrome?

ELESGARAY ROSANA; MEDINA AGUSTINA; PAEZ DIAMELA; DOMÍNGUEZ JUANA; HID EZEQUIEL; FARIÑA, GREGORIO; ZAGO VALERIA; CANIFFI, CAROLINA; ARRANZ CRISTINA; TOMAT ANALÍA

Mar del Plata

Congreso; REUNIÓN CONJUNTA SAIC SAB AAFE AACYTAL 2023; 2023

Introduction: The metabolic syndrome represents the association of various risk factors such as obesity, dyslipidemia, hyperglycemia and hypertension. Zinc deficiency is a common phenomenon in diabetic and obese patients.Objective: To evaluate the effects of zinc supplementation on retroperitoneal adipose tissue (RPAT), systolic blood pressure (SBP), and intermediate metabolism in male Wistar rats fed a high-fat and fructose diet during post-weaning growth.Methods: Male Wistar rats received from weaning (21 days) to 81 days of life: C: control diet (Zn2+: 30 ppm); CHF: high-fat diet (fat 60% kcal, Zn2+: 30 ppm) and fructose 10% in drinking water; ZHF: high-fat diet supplemented with zinc (fat 60% kcal, Zn2+: 190 ppm) and fructose 10% in drinking water. At day 81 SBP, plasma lipid profile, oral glucose tolerance test (OGTT) and RPAT morphology were evaluated. Values are mean±SEM. One-way ANOVA Bonferroni post-test: **p