Cardiovascular and metabolic effects of dietary zinc supplementation during growth on Wistar rats fed with high fat high fructose diets.

MEDINA AGUSTINA; PAEZ DIAMELA; DOMÍNGUEZ JUANA; ZAGO VALERIA; ELESGARAY ROSANA; CANIFFI CAROLINA; ARRANZ CRISTINA; TOMAT ANALÍA

Congreso; VI International Congress in Translational Medicine.; 2023

Background: Previously, we demonstrated an association between zinc deficiency during growth and the development of cardiometabolic alterations in adult male Wistar rats.Aim:To evaluate the effects of postnatal zinc supplementation on skeletal muscle, systolic blood pressure (SBP) and intermediate metabolism in male Wistar rats fed a high-fat and fructose diet during post-weaning growth.Methods: Male Wistar rats received from weaning, 21 days of life, up to 81 days of life: control diet (C, Zinc: 30 ppm), high fat diet (CHF; fat calories: 60%, Zinc: 30 ppm) and fructose at 10% in drinking water or a high-fat diet supplemented with zinc (ZHF; fat calories: 60%, Zinc: 190 ppm) and fructose at 10% in drinking water.On day 81, SBP, plasma lipid profile, oral glucose tolerance test, morphological changes in skeletal muscle and skeletal muscle vessels were determined.Statistics: Values are mean±SEM. ANOVA I Factor. Bonferroni: ***p